Avana 50mg Tablet

Description

What is Avana 50mg?

Avana 50mg tablet is used for the treatment of erectile dysfunction (impotence) in men. It works to enhance the penile blood flow by relaxing & increasing the smooth muscles & blood vessels. It contains Avanafil as an active ingredient used in the treatment of erectile dysfunction. Erectile dysfunction (ED) is a condition where a man is unable to achieve and/or maintain a penile erection adequate for sexual intercourse. It happens when there is decreased blood flow to the penis.

Avana is also very effective in treating the rare disease known as aspiratory blood vessel hypertension (PAH). It causes the blood vessel divider to relax, which reduces the weight and pneumonic blood vessel resistance. 

Avana 50mg (Avanafil) tablet is a phosphodiesterase type 5 inhibitor help men with erectile dysfunction (impotence) to achieve penile erection during intercourse.

What are The Uses of Avana 50mg Tablets?

Avana 50mg is used in men who are unable to achieve an erection during intercourse due to erectile dysfunction (impotence). It is used in the treatment of the following disorders:

• Erectile Dysfunction (ED)

This condition causes men to have trouble getting or keeping an erection long enough to have sexual intercourse. Having this problem occasionally is not a cause for concern. However, if it happens frequently, then it is best to seek medical attention. Psychological issues or underlying medical ailments may be the cause of ED. It causes stress, a lack of confidence, sexual refrainment, and relationship issues.

• Pulmonary Arterial Hypertension (PAH)

The right chambers of the heart pump blood to the lungs through the pulmonary arteries. In PAH, these arteries become constricted, which increases the blood pressure in them. This increases the burden on the heart. Some of the factors that can lead to the progression of this disease are genetics, HIV infection, congenital heart diseases, drug abuse, exposure to toxic materials, etc. However, only the avanafil suspension form is approved for the treatment of PAH, not the tablets. 

What are The Dosage Guidelines for Avana 50mg Tablets?

Patients’ responses to the initial dose and tolerance vary when it comes to the dosage of Avanafil 50 mg tablets. 15 to 30 minutes before engaging in sexual activity, the medication should be taken orally. It is advisable to take the prescribed amount once a day.

• A 50 mg initial dose can be taken with or without food.
• Depending on a person’s effectiveness and tolerance, the dosage can be raised up to 200 mg.
• 50 mg is the lowest dosage that is utilized.

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Missed Dosage Guidelines:

• Avana 50mg is taken as on needed basis.
• Do not take it if it is close to the time of the next dose. You can take next dose after 24 hours

Overdosage Guidelines:

The symptoms of Avana 50mg overdosage are given below. In such a situation, the patient is treated with supportive care. 

• Difficulty breathing
• Unconsciousness
• Seizures
• Blue green vision
• Blurred sight
• Abnormally enhanced side effects

How does The Avana 50mg Tablet Work?

Avana 50mg (Avanafil) is a medication used to treat male erectile dysfunction. It works to achieve an erection during intercourse. This element belongs to a category of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. To comprehend its mode of action, it is essential to delve into the physiological processes involved in achieving an erection.

Penis nerve terminals and endothelial cells emit nitric oxide during sexual stimulation. Nitric oxide starts guanylate cyclase working, which raises cGMP in smooth muscle cells in the penile artery and corpus cavernosum.

The elevated cGMP levels cause relaxation of the smooth muscle cells in the penile blood vessels, resulting in vasodilation (widening of the blood vessels) and increased blood flow to the penis. This increased blood flow leads to the engorgement of erectile tissues, ultimately resulting in an erection.

An enzyme known as phosphodiesterase type 5 (PDE5), however, controls the erection process by degrading cGMP and counteracting its effects. In individuals with erectile dysfunction (ED), the activity of PDE5 may be elevated, leading to insufficient levels of cGMP and impaired erectile function.

Avana 50mg works by selectively inhibiting the action of PDE5. Avanafil stops the breakdown of cGMP by blocking PDE5. This lets it build up and do its vasodilatory work without any problems. This results in enhanced smooth muscle relaxation, increased blood flow to the penis, and improved erectile function.

Note that Avana 50mg increases the natural erectile response to sexual stimulation and does not cause an erection. Sexual arousal and stimulation are needed for drug efficacy. This drug also improves erectile function and sexual activity for four to six hours.

What are The Side Effects of Avana 50mg Tablets?

Mild to moderate side effects of Avana 50mg are:

• Headaches
• Nausea
• Dizziness
• Flushing and redness of face
• Stuffed nose
• Nosebleed 

Even though they are uncommon, severe side effects need prompt medical attention. If any of these responses are seen, contact the emergency services right away:

• Priapism, i.e., painful and prolonged erections lasting more than 4 hours.
• Seizures
• Chest pain during or after sex
• Allergic reactions like difficulty breathing, swollen lips, face, eyes, and throat, hives, etc.
• Blurred vision
• Reduced hearing
• Mental depression
• Worsening of asthma 

Precautions & Warnings:

It’s essential to be aware of certain precautions and warnings to ensure safe and effective use. These precautions include:

• Consultation with a Healthcare Professional

If you are already taking other medicines or have a medical problem, you should talk to your PCP before starting Avana 50mg treatment. Healthcare personnel can use this meeting to see if you are a good candidate for the treatment and provide you with personalized advice based on your unique situation.

• Cardiovascular Health

Avana 50mg tablets may reduce blood pressure if taken with nitrates or alpha-blockers. Patients with heart disease or hypertension should use Avana 50mg cautiously and under medical supervision.

• Priapism

Avanafil can cause rare but serious priapism, a painful erection lasting more than four hours. To avoid penis injury, priapism patients should seek medical assistance immediately.

• Vision and Hearing Changes

Avanafil can cause impaired vision, light sensitivity, and, very rarely, abrupt vision loss. Avanafil and other PDE5 inhibitors might cause abrupt hearing loss or vertigo. Patients with these symptoms should stop taking Avana 50mg and visit a doctor.

• Allergic Reactions

Avoid Avana 50mg if you’re allergic to Avanafil or any of its constituents. Rashes, itching, swelling, and trouble breathing are allergic reactions that require medical attention.

• Driving and Operating Machinery

Avana 50mg pills may produce dizziness, which can impair driving or machinery operation. Before knowing how the drug affects them, people should avoid mentally demanding activities.

• Storage and Handling

Avana 50mg tablets should be stored at 20–25 °C, away from moisture and heat. Keep tablets away from children and pets and properly dispose of expired medication.

When Not to Take Avana 50mg Tablet ?

Avana 50mg tablets should not be taken in certain circumstances or conditions. Here are instances when this tablet should not be taken.

• Allergy or Hypersensitivity

People who are allergic to Avanafil, the active ingredient in Avana 50mg tablets, or any of its inactive constituents shouldn’t consume the drug. Allergic reactions range from a moderate rash and itching to serious respiratory problems. 

• Nitrate Medications

Nitrates or nitric oxide donors like nitroglycerin or isosorbide dinitrate should not be taken with Avana 50mg tablets. Avanafil with nitrates can cause a fast reduction in blood pressure, causing dizziness, fainting, or even hypotension.

• Alpha-Blockers

Alpha-blockers, used to treat hypertension or benign prostatic hyperplasia, can lower blood pressure if administered with Avana 50mg tablets. This combination should be avoided or used cautiously under medical supervision to reduce the hypotension risk.

• Riociguat

People receiving riociguat, a medicine for PAH and CTEPH, should not take Avana 50mg pills. Avoid using Avanafil and riociguat together because they can cause hypotension.

• Severe Liver or Kidney Impairment

Heavy liver or kidney impairment may require dosage adjustments or specific monitoring when taking Avana 50mg tablets. Due to inadequate safety and efficacy data, the medicine should be avoided in those with severe hepatic (liver) impairment or end-stage renal illness needing dialysis.

• Recent Stroke or Heart Attack

Patients who have had a stroke or myocardial infarction within six months are prohibited from taking Avana 50mg pills. The medicine may worsen cardiovascular issues and be hazardous.

• Hereditary Eye Disorders

Users of Avana 50mg tablets should be careful because they might cause vision problems in people who have retinitis pigmentosa or other inherited degenerative retinal diseases

Interactions:

Avana 50mg tablets can interact with specific medications and substances, potentially affecting their effectiveness, increasing the risk of side effects, or causing adverse reactions. Some notable interactions include:

• Nitrates

Combining Avana 50mg with medications containing nitrates or nitric oxide donors, such as nitroglycerin or isosorbide dinitrate, can lead to a significant drop in blood pressure (hypotension). This combination should be avoided due to the risk of severe cardiovascular complications.

• Alpha-Blockers

Concurrent use of Avana 50mg with alpha-blockers, medications for hypertension or benign prostatic hyperplasia, can potentiate their hypotensive effects, causing lightheadedness, dizziness, or fainting. Caution is advised, and dosage adjustments may be necessary.

• Other Antihypertensive Medications

Other antihypertensive drugs, like calcium channel blockers, beta-blockers, and angiotensin-converting enzyme (ACE) inhibitors, may work better when taken with Avana 50mg. Close monitoring of blood pressure is recommended, and dosage adjustments may be necessary to prevent symptomatic hypotension.

• Riociguat

Patients taking riociguat, a drug for pulmonary arterial hypertension, should not take Avana 50mg at the same time because of the high risk of severe hypotension and bad cardiovascular events.

• Grapefruit Juice

Grapefruit juice can slow down the metabolism of Avanafil. This can cause blood levels to rise and the risk of side effects to rise as well. Avoid drinking grapefruit juice while you are on Avana 50mg.

• Alcohol

Alcohol can make the hypotensive effects of Avana 50mg stronger and raise the risk of side effects like feeling dizzy, lightheaded, or passing out. Limiting alcohol use is suggested while taking Avanafil.

• Drugs Metabolized by Cytochrome P450 Enzymes

The cytochrome P450 (CYP) 3A4 enzyme pathway is the main way that Avanafil is broken down. CYP3A4 inhibitors or inducers may change how Avanafil is broken down and cleared from the body, which could change how well it works or make side effects more likely. Examples include ketoconazole and ritonav.

FAQs:

1. How much time does it take for this medication to start working?

Ans: The onset of action of this medication might be detected within 30 to 60 minutes after it is administered.

2. What is the duration of the effects of this medication?

Ans: The duration of action of this medication in the body is 5 hours.

3. Is it advisable to consume alcohol while taking this medication?

Ans: Avoid or limit alcohol consumption while taking this medication to minimize the heightened risk of severe side effects such as dizziness, fainting, flushing, persistent headaches, and changes in heart rate.

4. Is this medication habit-forming?

Ans: No addictive properties were reported.

5. Is this medication safe for use during pregnancy?

Ans: Pregnant women should avoid using this medication.

6. Is it safe to consume this medication while breastfeeding?

Ans: It is advised against using this medication in women who are breastfeeding.